Table 1.
Anorectal pressures and rectal sensation in first and second studies
| Parameter | Healthy participants (N=22) | Constipated patients (N=53) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| First study Mean (SD) | Second study Mean (SD) | CCC (95% CI) | Coefficient of variation (%) | First study Mean (SD) | Second study Mean (SD) | CCC (95% CI) | Coefficient of variation (%) | |||
| Intraindividual | Interindividual | Intraindividual | Interindividual | |||||||
| Anal resting pressure, mmHg | 79 (19) a | 90 (28) | 0.55 (0.23, 0.75) | 20 | 21 | 91 (26) | 94 (23) | 0.62 (0.43, 0.76) | 16 | 21 |
| Anal squeeze pressure, mmHg | 225 (62) | 217 (58) | 0.67 (0.36, 0.85) | 15 | 24 | 204 (72) | 205 (70) | 0.65 (0.47, 0.79) | 20 | 28 |
| Squeeze c duration, s | 12 (7) | 14 (6) | 0.76 (0.45, 0.91) | 24 | 44 | 14 (5) | 13 (6) | 0.26 (0.01, 0.50) | 36 | 22 |
| Evacuation | ||||||||||
| Rectal pressure, mmHg | 36 (22) | 29 (18) | 0.39 (0 .01, 0.68) | 48 | 40 | 28 (25) | 33 (28) | 0.52 (0.30, 0.69) | 61 | 63 |
| Anal pressure, mmHg | 69 (18) b | 82 (20) | 0.16 (−0.18, 0.47) | 26 | 8 | 89 (21) | 92 (27) | 0.56 (0.36, 0.72) | 18 | 20 |
| Rectoanal gradient, mmHg | −33 (30) | −53 (21) | 0.34 (0.04, 0.59) | 55 | 34 | −61 (28) | −59 (30) | 0.42 (0.17, 0.62) | 36 | 32 |
| Rectal sensation thresholds (ml) d | ||||||||||
| First sensation, ml | NA | 50 (24) | 40 (51) | 0.43 (0.21, 0.61) | 66 | 58 | ||||
| Urgency, ml | NA | 88 (41) | 77 (54) | 0.72 (0.52, 0.84) | 31 | 49 | ||||
| Discomfort, ml | NA | 129 (49) | 122 (67) | 0.55 (0.29, 0.74) | 31 | 35 | ||||
CCC: Concordance correlation coefficient; CI: confidence interval; NA: not available.
a
P =0.018
b
P = 0.014 vs corresponding parameter in the second study
c
Data available for 50 constipated and 14 healthy participants;
d
Data available for 32 constipated patients