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. Author manuscript; available in PMC: 2023 Jun 2.
Published in final edited form as: Cancer Discov. 2022 Dec 2;12(12):2838–2855. doi: 10.1158/2159-8290.CD-22-0027

Figure 4. PCa-risk SNP rs8102476 and the transcriptional regulation of PPP1R14A and SPINT2.

Figure 4.

(A) Integrated genome view of PCa-risk SNP rs8102476 and its adjacent regions. ChIA-PET and ChIP-Seq tracks for various factors in LNCaP, VCaP and DU145 cells are shown. (B and C) The mRNA abundance (FPKM) of PPP1R14A and SPINT2 were validated in TCGA and CPC-GENE cohorts. FDR was calculated by “BH” method, and β value were estimated from linear regression model. (D) The protein abundance of PPP1R14A in CPC-GENE cohort.