Table 2.

Post hoc t-tests for pairwise contrasts between groups using ROI analysis (Marsbar, see methods).

STUDY AND ROI	Contrast 1		Contrast 2		Contrast 3		Contrast 4		Contrast 5		Contrast 6
FAMPATH	HV > HR		HV > HR-MOOD		HV > HR-MOOD+SA		HR > HR-MOOD		HR > HR-MOOD+SA		HR-MOOD > HR-MOOD+SA
	t(85)	p-val	t(85)	p-val	t(85)	p-val	t(85)	p-val	t(85)	p-val	t(85)	p-val
vmPFC	0.69	0.25	3.12	0.001	3.50	0.0004	2.44	0.008	2.83	0.003	0.57	0.29
mOFC	1.37	0.09	3.67	0.0002	3.08	0.001	2.27	0.01	1.75	0.04	−0.40	0.65
SECOND DATASET	HV and non-HR patients > “HR”*		HV > MOOD		HV > MOOD+SA		N/A		N/A		MOOD > MOOD+SA
	diff	p-val	t(87)	p-val	t(87)	p-val					t(87)	p-val
vmPFC	0.11	0.16	0.21	0.42	−0.14	0.56					0.11	0.46
mOFC	0.08	0.37	−0.71	0.76	0.29	0.39					0.42	0.34

^*The diff column lists the difference in medians between the two groups, and p-val is based on a Mann-Whitney U-test. See Figure 1A (right panel) and Figure 1B for voxel-wise results when using an anatomic ROI and small volume cluster-extent correction.

vmPFC=dorsal cluster in Figure 1, top row; mOFC=ventral cluster in Figure 1, bottom row; All reported p-values in the table are one-sided since we hypothesized specific directions in the second independent dataset based on FAMPATH dataset results.