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. 2022 Dec 6;26(1):105748. doi: 10.1016/j.isci.2022.105748

Figure 1.

Figure 1

Analysis of serum levels of alveolar tissue injury markers using enzyme-linked immunosorbent assays (ELISAs)

(A-F) soluble receptors for advanced glycation end products (sRAGE), (B) angiopoietin (ANG)-2, and (C) surfactant protein (SP)-D levels in the serum of patients with COVID-19 with or without acute respiratory distress syndrome (ARDS) at admission (on the first or second hospital day), and healthy controls are shown. Bidaily temporal changes in (D) sRAGE, (E) ANG-2, and (F) SP-D in sera of COVID-19 patients with ARDS during the first 8 days after hospital admission are shown. In cases in which multiple values every 2 days were available, mean values were used. When only a single value was available, the value was used.

(G) Days in which concentrations of each alveolar tissue injury marker peaked in COVID-19 patients with ARDS are shown. Values are presented as medians with interquartile ranges. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.0001.