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. 2022 Dec 6;26(1):105748. doi: 10.1016/j.isci.2022.105748

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Analysis of lung tissue transcriptomes in the COVID-19 mouse model in the present study and previously reported infection models

(A) Top 10 upregulated and downregulated REACTOME pathways in the severe COVID-19 mouse model in the present study.

(B-D) Reciprocal GSEA (C) Heatmap of NES in each dataset, and (D) correlation between the NES of the severe COVID-19 model in the present study and the mean NES of previously reported infection models. In these analyses (C, D), REACTOME pathways significantly changed at least in one dataset were included.