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. 2022 Dec 6;26(1):105748. doi: 10.1016/j.isci.2022.105748

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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An analysis of effects of high-mobility group box (HMGB)-1 neutralization on alveolar tissue injury in a mouse model of severe COVID-19

(A-G) White blood cell count, (B) total protein, (C) soluble receptors for advanced glycation end products (sRAGE), (D) angiopoietin (ANG)-2, (E) total CK18, (F) CK18-M30 levels, and (G) the ratio of CK18-M30/total CK18in BALF from the mouse model of severe COVID-19 treated with an anti-HMGB-1 neutralizing antibody or an isotype control antibody are shown. Values are presented as means ± SE. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.0001.