Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 4;54(11):1886–1900. doi: 10.1038/s12276-022-00874-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a UMAP plots depict subsets of identified Schwann cell clusters. Data sources: Tracy Tabib et al., 2018 (TT)¹⁸; Xuanyu Liu et al., 2021 (XL)¹⁵, Cheng-Cheng Deng et al., 2021 (CCD)¹⁶, Martin Direder et al., 2021 (MD)¹⁷; b Dot plots of well-known marker genes to characterize Schwann cell subtypes. MBP, MPZ, PLP1, and PMP22 for myelinating Schwann cells (SC-Myel); NCAM1, L1CAM, and SCN7A for nonmyelinating Schwann cells (SC-Nonmyel, SC-Nonmyel2); S100B and NGFR as general Schwann cell markers; NES, IGFBP5, CCN3 for keloidal Schwann cells (SC-Keloid); TOP2A and MKI67 for proliferating Schwann cells (SC-Prolif), DCN and LUM for cells expressing Schwann cell and fibroblast-specific genes (SC-FB), ICAM1 and SELE for cells expressing Schwann cell and endothelial cell-specific genes (SC-EC); mixed myelinating and nonmyelinating Schwann cell cluster (SC-Myel+Nonmyel); Color codes indicate average gene expression levels; Dot sizes visualize relative amounts of positive cells. c Feature blends reveal cells positive for S100B (green) and LUM (red) and double-positive cells (yellow). d Bar plots show the absolute cell count of distinct Schwann cell clusters in each included dataset. skin (s), normal scar (ns), keloid (k); data source: Tracy Tabib et al., 2018 (TT)¹⁸; Xuanyu Liu et al., 2021 (XL)¹⁵, Cheng-Cheng Deng et al., 2021 (CCD)¹⁶, Martin Direder et al., 2021 (MD)¹⁷.