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. 2022 Nov 22;13:1026938. doi: 10.3389/fendo.2022.1026938

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Copyright © 2022 Zhang, Hu, Zhu, Li and Fang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DE-MRGs. (A) Volcano diagram shows the DEGs in HC and DN group. The threshold for screening the DEGs is set at |Fold Change| ≥ 1 and P -value < 0.05. (B) Heatmap shows the top 30 up-regulated and down-regulated DE-MRGs in HC and DN group. (C) Principal component analysis illustrates a significant difference between the HC and DN samples based on the MRGs.