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. 2022 Nov 22;10:1057913. doi: 10.3389/fbioe.2022.1057913

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Copyright © 2022 Wang, Zhang, Li and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human monocytes were cultured in collagen gels together with the labeled human HCC cell line HepG2 (HepG2-preS1-GFP), while hepatitis B virus (HBV)-specific TCR T cells passed through the tumor aggregation zone from both sides of the fluid channel to mimic the dynamic microenvironment of hepatitis B virus (HBV)-related hepatocellular carcinoma. Adapted under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/4.0/). Copyright: Lee et al. (2018), Adriani, Ceccarello, Pavesi, Tan, Bertoletti, Kamm and Wong.