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. 2022 Nov 22;13:1032314. doi: 10.3389/fimmu.2022.1032314

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Copyright © 2022 Hou, Yi and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predictive biomarkers of colon cancer immunotherapy MSI, microsatellite instability; TMB, total mutation burden; POLE:/POLD1, DNA polymerase ϵ (POLE) and δ (POLD1); TILs, tumor-infiltrating lymphocytes; PD-L1, programmed cell death-ligand 1; TLS, tertiary lymphoid structure; CAF, cancer-associated fibroblast; ctDNA, circulating tumor DNA; bTMB, blood total mutation burden; NLR, neutrophil-lymphocyte ratio.