Table 2.
Effect of CCM treatment on lesion scoring of the cochlear structures of the ear of GEN or NaS administered rats
| Lesions | Control | OO | CCM | GEN | NaS | CCM+GEN | CCM+NaS |
|---|---|---|---|---|---|---|---|
| Spiral ganglion | |||||||
| Necrotic neurons | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 3.17* ± 0.26 | 3.50* ± 0.29 | 1.67*# ± 0.36 | 1.83*# ± 0.51 |
| Vacuolation | 0.17 ± 0.14 | 0.17 ± 0.14 | 0.33 ± 0.18 | 2.67* ± 0.18 | 1.17* ± 0.34 | 1.17*# ± 0.26 | 0.83 ± 0.26 |
| Decreased number of spiral ganglion cells | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 2.17* ± 0.34 | 1.83* ± 0.26 | 1.17*# ± 0.14 | 1.00*# ± 0.22 |
| Stria vascularis | |||||||
| Cracking of epithelium | 0.67 ± 0.28 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.83* ± 0.26 | 2.83* ± 0.34 | 0.50 ± 0.29 | 1.17*# ± 0.40 |
| Congested capillaries | 0.00 ± 0.00 | 0.67 ± 0.18 | 0.67 ± 0.18 | 1.00 ± 0.00 | 2.05* ± 0.34 | 1.00 ± 0.31 | 1.50* ± 0.29 |
| Organ of Corti | |||||||
| Loss of hair cells | 0.00±0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 4.17* ± 0.34 | 2.83* ± 0.34 | 3.00*# ± 0.22 | 1.83*# ± 0.26 |
Values are represented as the mean ± SE. n = 10 replicates/treatment
OO olive oil
*Significantly different compared to the control group (i.e., GEN, NaS, GEN+CCM, or CCM+NaS vs. control group) at P < 0.05
#Significantly different from the respective drug only treated group (i.e., CCM+GEN vs. GEN and CCM+NaS vs. NaS) compared to the control group at P < 0.05