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. 2022 Dec 5;12:20975. doi: 10.1038/s41598-022-25389-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Volume dependency of error metrics. (a) Shows the comparison of error metrics between all BMs, BMs with volume < 7.5 cc, and BMs with volume > 7.5 cc before the removal of any volume-correlated features. (b–d) show the AUC, FNR, and FPR for each BM volume group as a function of the feature volume-correlation coefficient threshold value used to remove continuous features, with correlation threshold = 1 corresponding to the removal of no features (baseline). At all correlation thresholds < 1, categorical clinical features dependent on BM volume are also removed. For example, values at correlation threshold = 0.7 represent the error metric values when the experiment was repeated with all features with volume-correlation coefficient values greater than 0.7 removed. For all values, a 95% confidence interval is provided by error bars or shaded bands.