Table 3.
The hazard ratios for mortality according to tertiles of B-type natriuretic peptide.
| Unadjusted HR (95% CI) |
Model 1a (95% CI) |
Model 2b (95% CI) |
Model 3c (95% CI) |
Model 4d (95% CI) |
|
|---|---|---|---|---|---|
| All patients | |||||
| Tertile 1* | REF | REF | REF | REF | REF |
| Tertile 2† | 4.43 (3.38–5.81) | 2.62 (1.99–3.47) | 2.66 (2.01–3.52) | 2.57 (1.93–3.42) | 2.64 (1.96–3.55) |
| Tertile 3‡ | 9.01 (6.96–11.67) | 4.60 (3.51–6.04) | 4.68 (3.56–6.14) | 4.18 (3.15–5.57) | 4.18 (3.09–5.64) |
| Patients with acute HMOD | |||||
| Tertile 1* | REF | REF | REF | REF | REF |
| Tertile 2† | 3.98 (2.59–6.13) | 2.28 (1.46–3.54) | 2.27 (1.46–3.52) | 2.19 (1.40–3.44) | 2.16 (1.36–3.42) |
| Tertile 3‡ | 8.43 (5.64–12.58) | 3.79 (2.49–5.77) | 3.76 (2.47–5.72) | 3.44 (2.22–5.33) | 3.24 (2.07–5.10) |
| Patients without acute HMOD | |||||
| Tertile 1* | REF | REF | REF | REF | REF |
| Tertile 2† | 4.77 (3.37–6.75) | 3.02 (2.10–4.35) | 3.13 (2.17–4.51) | 3.02 (2.07–4.40) | 3.24 (2.19–4.81) |
| Tertile 3‡ | 9.42 (6.65–13.34) | 5.44 (3.76–7.86) | 5.82 (4.01–8.44) | 5.01 (3.38–7.44) | 5.24 (3.44–7.99) |
HR, hazard ratio; CI, confidence interval; REF, reference.
*The range of BNP levels in tertile 1 is ≤ 37 pg/mL.
†The range of BNP levels in tertile 2 was between > 37 and < 167 pg/mL.
‡The range of BNP levels in tertile 3 is ≥ 167 pg/mL.
aModel 1: Adjusted for age and sex.
bModel 2: Adjusted for age, sex, systolic blood pressure, and diastolic blood pressure.
cModel 3: Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, and comorbidities (hypertension, diabetes mellitus, ischemic stroke, hemorrhagic stroke, heart failure, coronary artery disease, chronic kidney disease, and end-stage renal disease).
dModel 4: Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, comorbidities (hypertension, diabetes mellitus, ischemic stroke, hemorrhagic stroke, heart failure, coronary artery disease, chronic kidney disease, and end-stage renal disease), and components of hypertension-mediated organ damage (estimated glomerular filtration rate, cardiomegaly on chest radiography, left ventricular hypertrophy on electrocardiography, and myocardial ischemia on electrocardiography).