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. 2022 Dec 5;13:7496. doi: 10.1038/s41467-022-34732-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — RBD REM sleep behavior disorder, GWAS genome-wide association study. Regional association plots for eQTL (upper pane) and RBD GWAS association signals (lower pane) in the regions surrounding a SNCA-AS1 (colocalization PPH4 = 0.89) and b MMRN1 (colocalization PPH4 = 0.86). eQTLs are derived from a PsychENCODE’s analysis of adult brain tissue from 1387 individuals or b the eQTLGen meta-analysis of 31,684 blood samples from 37 cohorts. In a and b, the x-axis denotes chromosomal position in hg19, and the y-axis indicates association p-values from across-locus logistic (RBD GWAS) or linear (eQTL) regression on a –log₁₀ scale. Plot of SNCA-AS1 and MMRN1 specificity in c 35 human tissues (GTEx dataset) and d 7 broad categories of cell type derived from human middle temporal gyrus (AIBS dataset). Specificity represents the proportion of a gene’s total expression attributable to one cell type/tissue, with a value of 0 meaning a gene is not expressed in that cell type/tissue and a value of 1 meaning that a gene is only expressed in that cell type/tissue. In c tissues are colored by whether they belong to the brain. In c and d, tissues and cell types have been ordered by specificity from high to low.