Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 5;13:7496. doi: 10.1038/s41467-022-34732-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — GTEx Genotype-Tissue Expression Consortium, v8 version 8, RBD REM sleep behavior disorder, PD Parkinson’s disease, eQTL expression quantitative trait loci. All data was extracted from the GTEx online portal (https://www.gtexportal.org/). The effect sizes represent the slope of linear regression on normalized gene expression data versus the genotype status using single-tissue eQTL analysis, performed by the GTEx consortium. Nominal associations are indicated with* (p < 0.05) while FDR-corrected significant associations are indicated with**. FDR correction q-values were calculated using beta distribution-adjusted empiracle p-values, derived from adaptive permutations during eQTL mapping. Dark gray indicates missing data in these tissues. The RBD SNCA variant correlates most strongly with decreased SNCA-AS1 expression in the cerebellum (uncorrected p = 9.9e-19) cerebellar hemisphere (p = 3.1e-08), cortex (p = 1.9e-05), frontal cortex (p = 6.3e-05), and anterior cingulate cortex (p = 2.6e-04). The PD variant only significantly correlates with decreased expression in the anterior cingulate cortex (p = 2.5e-05).