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. 2022 Dec 5;13:7496. doi: 10.1038/s41467-022-34732-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — RBD REM sleep behavior disorder. We used WebGestalt (http://www.webgestalt.org/) to perform gene-set enrichment analysis in cellular components and biological processes. Enrichment scores are calculated similar to Kolmogorov–Smirnov statistics; they indicate whether a group of genes is over- or under-represented in a list of processes. Two-sided p-values are calculated by comparison to the enrichment scores null distribution, produced with phenotypic permutation testing. Bars on this plot represent the unadjusted p-values for pathways nominated by gene-set enrichment analysis. All pictured pathways are significant after FDR multiple testing correction.