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. 2022 Dec 5;13:7496. doi: 10.1038/s41467-022-34732-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — PD Parkinson’s disease, RBD REM sleep behavior disorder, GWAS genome-wide association study, pRBD probable RBD, DLB dementia with Lewy bodies. We compare significance and direction of PD GWAS-nominated loci to this study’s summary statistics for iRBD (a), PD+pRBD (b), the meta-analysis (c), and in the previously published DLB summary statistics (d). Colored points indicate variants with the same (blue) or opposite (red) direction of effect in both studies, with a nominally significant p-value (p < 0.05) in their respective genome-wide association studies (two-sided p-value derived from logistic regression across the genome). All test statistics for each cohort can be found in Supplementary Table 5. Gray points are those with undetermined direction (p > 0.05 and confidence intervals cross 0). The shapes of the points indicate the number of synucleinopathy GWAS where the locus reaches GWAS significance (counting PD, PD age at onset, DLB, and this RBD meta-analysis). Gene names indicate the closest gene to the represented variant.