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. 2022 Nov 28;54(11):2077–2091. doi: 10.1038/s12276-022-00889-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The pathway of citrate metabolism and transport. b Expression of Idh3α, Sdhα, Slc25a1, and Acly mRNA in the lungs 12 h after LPS or normal saline treatment. The fold changes were calculated relative to the saline group (n = 6–8). c–f Representative immunoblots of lung tissue lysates 12 h after LPS treatment showing decreased protein levels of IDH3α and CIC (n = 6 mice per group) and increased citrate^mt but not citrate^cy in the lungs of ALI mice (n = 8–9 mice per group). g–j IDH3α and CIC mRNA and protein levels were downregulated, whereas increased citrate^mt was observed in LPS-treated MLE12 cells (n = 3). The data are shown as the mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001.