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. 2022 Nov 28;54(11):2077–2091. doi: 10.1038/s12276-022-00889-8

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Fig. 8 — LPS downregulates Idh3α and Slc25a1, leading to citrate^mt accumulation in AECs. Citrate^mt accumulation induces DRP1-mediated mitochondrial fission and excessive mitophagy via FUNDC1, which damages mitochondria in AECs. As a consequence of RIPK3 activation, MLKL is phosphorylated and activated, which leads to AEC necroptosis and ALI/ARDS.