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. 2022 Dec 5;13:7494. doi: 10.1038/s41467-022-34460-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Relative abundances of upregulated proteins in the three immune subtypes and associations of immune subtypes with clinical and genetic features and proteomic subtypes (Fisher’s exact test). b Kaplan–Meier curves of OS for the three immune subtypes (two-sided log-rank test). c Comparison of pathway scores for the Complement Cascade and EMT among immune subtypes (IM1, n = 19; IM2, n = 27; IM3, n = 28). Boxplots show the median (central line), the 25–75% IQR (box limits), and the ±1.5 × IQR (whiskers). P values are derived from Kruskal–Wallis test. d Scatter plot showing the correlation of EMT scores and xCell immune signatures. Fibroblasts are indicated. e Ternary plot showing the distribution of significant arm-level events in the three immune subtypes. CNA events with significant differences among three subtypes are indicated (Fisher’s exact test). f Proteasome showing the highest correlation with 14q CN. g Cis and trans-effects of 14q deletion on proteasome. h Correlation of proteasome scores and EMT scores (two-sided Spearman’s correlation test). i A model depicting the association of 14q deletion and immune signature in tRCC.