FIGURE 2.

The CD70 gene is frequently targeted by mutations and deletions in diffuse large B‐cell lymphoma (DLBCL). (A) Schematic diagram representing the distribution of mutations identified in the CD70 gene in tumour samples from Chinese (CHN, red symbols) and Swedish DLBCL (SWE, purple symbols) patients. Mis, missense mutation; Mut, mutation; Trunc, truncation mutation. (B) Distribution of CD70 homozygous (copy number = 0) and heterozygous (copy number = 1) deletions in CHN and SWE DLBCL tumour samples. χ²‐test, P > 0.6585. (C) Comparison of the frequency of CD70 mutations and copy number variations in CHN and SWE DLBCL tumour samples. Mut and copy number loss: mutation and copy number loss; χ²‐test, **P = 0.0095.