Table 2.
Characteristics of the cohort. Cohort was imputed using multivariate imputation by chained equations10. All proportions and means are specified together with their 95% confidence interval. Table S1 provides the characteristics of the non-imputed dataset with percent missing denoted as [%]. Mean values for the metabolic factors are in Table S1.
| Characteristic | Healthy CAP < 290 dB/m N = 2732 |
Hepatic Steatosis CAP ≥ 290 dB/m LSM < 8.2 kPa, N = 1234 |
Fibrosis LSM ≥ 8.2 kPa N = 403 |
|---|---|---|---|
| Mean Age, years | 44.3 (42.9, 45.7) | 50.3 (49, 51.4) | 51.6 (49.1, 54.2) |
| Sex, % | |||
| Female | 55.9 (53.4, 58.4) | 42.9 (39.2, 46.6) | 38.3 (31.5, 45.2) |
| Male | 44.1 (41.6, 46.6) | 57.1 (53.4, 60.8) | 61.7 (54.8, 68.5) |
| Ethnicity, % | |||
| Non-hispanic Whites | 63.3 (58.2, 68.3) | 63.5 (56.7, 70.3) | 61 (52.6, 69.3) |
| Non-hispanic Asians | 5.2 (3.3, 7.1) | 4.9 (3.1, 6.6) | 3.7 (1.7, 5.6) |
| Non-hispanic Blacks | 12 (8.7, 15.3) | 7.5 (5, 10) | 10.3 (5.4, 15.2) |
| Hispanics | 14.7 (11.1, 18.2) | 19.9 (14, 25.8) | 19.6 (14, 25.1) |
| Others | 4.9 (3.5, 6.3) | 4.2 (2.4, 6) | 5.6 (2.6, 8.5) |
| Diabetes, % | 6.7 (5.5, 7.9) | 23.2 (19.9, 26.4)) | 39.5 (32.7, 46.3) |
| Lean: BMI ≤ 25 kg/m2 / 23 kg/m2 (non-Asian/Asian), % | 38.8 (34.9, 42.7) | 5 (2.8, 7.2) | 11.3 (5.9, 16.7) |
| Overweight: BMI 25-30 kg/m2 / 23-25 kg/m2 (Caucasian/Asian), % | 34 (31.6, 36.4) | 25 (20.9, 29.1) | 11.1 (7.8, 14.5) |
| Obese: BMI ≥ 30 kg/m2 / 25 kg/m2 (non-Asian/Asian), % | 27.2 (23.3, 31.2) | 70 (64.3, 75.8) | 77.5 (71.1, 84) |
| Metabolic Factors, % | |||
| 0 Metabolic Factors | 19 (15.8, 22.3) | 1.9 (0.9, 2.9) | 4.4 (−0.6, 9.3) |
| 1 Metabolic Factor | 26.2 (22.8, 29.6) | 6.3 (3.9, 8.8) | 7.6 (1.8, 13.5) |
| 2 or more Metabolic Factors | 54.8 (50.6, 59) | 91.8 (89.2, 94.4) | 88 (81.5, 94.4) |
| Waist circumference ≥ 102cm/90cm (non-Asian/Asian men), ≥ 88cm/80cm (non-Asian/Asian women), % | 46.1 (41.6, 50.5) | 86.3 (83.3, 89.2) | 85.4 (79.9, 90.8) |
| HOMA-IR ≥ 2.5, % | 33.1 (27.7, 38.6) | 74.4 (69.4, 79.4) | 78.6 (71, 86.1) |
| hsCRP > 2.0 mg/L, % | 36.4 (32.2, 40.6) | 60.5 (55.9, 65.2) | 71.6 (66.2, 76.9) |
| Fasting glucose:100 mg/dL to 125 mg/dL or A1C: 5.7% to 6.4%, % | 36.5 (32.7, 40.2) | 44.8 (40.9, 48.8) | 30.6 (23.7, 37.5) |
| HDL-C < 40 mg/dL (men), < 50 mg/dL (women), % | 20.9 (18.5, 23.2) | 39.5 (35.3, 43.8) | 38.9 (32, 45.9) |
| Fasting triglyceride ≥ 150 mg/dL, % | 7.5 (5.7, 9.3) | 18.6 (14.7, 22.4) | 16.5 (10.6, 22.4) |
| Systolic/Diastolic blood pressure ≥ 130/85 mmHg, % | 6.3 (4.6, 8.1) | 13.8 (11.2, 16.3) | 15.6 (11, 20.2) |