Table 1.
Characteristics by MN State area deprivation index ranking quantile in participants without dementia.
| State Area Deprivation Index Ranking Quintiles |
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|---|---|---|---|---|---|---|
| Characteristics‡ | 1st (N=1094) | 2nd (N=1057) | 3rd (N=962) | 4th (N=1158) | 5th (N=428) | p value† |
|
| ||||||
|
Study baseline (first visit between 2008–2018) |
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| Age (years) | 71.3 (10.1) | 71.0 (11.0) | 72.8 (10.2) | 75.7 (9.9) | 74.4 (11.2) | <0.001 |
| Sex (male), N (%) | 617 (56.4) | 545 (51.6) | 466 (48.4) | 544 (47.0) | 194 (45.3) | <0.001 |
| APOE ε4, any ε4, N (%) (n=4491) | 274 (26.5) | 280 (28.1) | 260 (28.1) | 318 (28.4) | 113 (27.4) | 0.88 |
| Education (years), (n=4693) | 15.0 (2.8) | 14.6 (2.6) | 14.4 (2.7) | 14.2 (2.7) | 13.7 (2.6) | <0.001 |
| Global cognitive z- score§ (n=4364) | -0.1 (1.1) | -0.1 (1.2) | -0.2 (1.1) | -0.5 (1.1) | -0.5 (1.2) | <0.001 |
| MCI (yes), N (%) | 104 (9.5) | 124 (11.7) | 111 (11.5) | 167 (14.4) | 75 (17.5) | <0.001 |
| Charlson Index ± | 2.9 (3.1) | 2.9 (3.1) | 2.8 (2.8) | 3.6 (3.3) | 3.6 (3.1) | <0.001 |
|
Follow-up
|
||||||
| Number of study visits | 4.4 (2.5) | 4.3 (2.4) | 4.5 (2.6) | 4.4 (2.6) | 4.1 (2.6) | 0.070 |
| Study follow-up (years) ^ | 4.5 (3.4) | 4.4 (3.2) | 4.7 (3.4) | 4.6 (3.5) | 4.2 (3.4) | 0.078 |
| Follow-up for incident dementia (years) ~ | 5.5 (3.2) | 5.4 (3.1) | 5.8 (3.2) | 5.9 (3.3) | 5.5 (3.3) | 0.003 |
| Incident Dementia,≠ N (%) (n=4678) | 86 (7.9) | 84 (8.0) | 92 (9.6) | 154 (13.4) | 76 (17.8) | <0.001 |
Abbreviations: APOE = apolipoprotein E; MCI= Mild cognitive impairment.
Mean (standard deviation) unless otherwise specified; the column also includes the number of participants with available data for variables that had missing data, otherwise n=4699.
ANOVA (continuous variables) or Chi-Square test (categorical variables).
Global cognitive z scores computed after scaling raw cognitive test scores (mean = 0, SD = 1) using data for cognitively unimpaired participants at baseline. Domain specific z scores are summed and scaled to obtain global z scores.
Excluding dementia.
From baseline to last in-person follow-up.
Either until last active follow-up visit or last medical record review date for participants who dropped from active follow-up.
Dementia cases ascertained by medical record review were also included.