Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 4;38(12):1569–1587. doi: 10.1007/s12264-022-00959-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Compensatory pathways during the acute stage after different CNS injuries. A1 After a local motor cortical lesion, significant reorganization occurs in the perilesional areas to compensate for the injured region. A2 The contralesional cortex controls the ipsilesional cortex by functional cortico-cortical connections to compensate for the lesion in a moderate cortical lesion. A3 A severe cortical lesion affects interhemispheric inhibition, while the cortex on the injured side completely loses its function, and the contralesional cortex directly controls the paretic side. B The cortico-rubro-spinal pathway is enhanced after damage to the internal capsule or brainstem pyramid. The reticulospinal tracts can be another compensatory pathway after pyramidal lesions. C After a DLF lesion, the spared propriospinal tract connecting different segments of the spinal cord plays an important role in functional recovery. D CST axons from the ipsilesional cortex sprout and cross below the lesion after hemisection of the spinal cord.