TABLE 2.

Demographic, biochemical and clinical profile of study population and comparison between HCC, CLD and Healthy cohorts.

Sr. No	Variable	Healthy (n = 30)	CLD (n = 100)	HCC (n = 100)	p value
1	Age (Year, Mean ± SD)	29.62 ± 7.63	36.08 ± 14.22	54 ± 13.14	0.001
2	Sex (n, %)	8 (27%)	67 (67%)	84 (84%)	0.008
	Male	22 (73%)	33 (33%)	16 (16%)
	Female
3	Etiologies (n, %)	-	65 (65%)	45 (45%)	0.004
	HBV	-	22 (22%)	16 (16%)	0.28
	HCV	-	6 (6%)	8 (8%)	0.58
	Alcohol	-	-	6 (6%)	----
	HBV + Alcohol	-	-	2 (2%)	-----
	HCV + Alcohol	-	2 (2%)	5 (5%)	0.25
	HVOTO	-	5 (5%)	11 (11%)	0.11
	NASH	-	-	3 (3%)	----
	HBV + HCV	-	-	4 (4%)	-----
	Cryptogenic
4	Child’s Score	-	-	88 (88%)	NA
	A	-	-	11 (11%)
	B	-	-	1 (1%)
	C
5	BCLC Stage	-	-	45 (45%)	NA
	A	-	-	38 (38%)
	B	-	-	15 (15%)
	C	-	-	2 (2%)
	D
6	PST Score	-	-	71 (71%)	NA
	0	-	-	24 (24%)
	1	-	-	03 (3%)
	2	-	-	02 (2%)
	3
7	Type II Diabetes Mellitus (n, %)	-	8 (8%)	21 (21%)	0.07
8	Cirrhosis	-	32 (32%)	89 (89%)	0.001
9	AFP (ng/ml)	-	-	14,835.2 ± 113,567.5	NA
	<20 (ng/ml)	-	-	22 (22%)
	>20 (ng/ml)			78 (78%)
10	Serum Albumin (g/dl)	-	4.45 ± 0.68	4.25 ± 4.52	0.64
11	Bilirubin (mg/dl)	-	0.85 ± 0.59	1.34 ± 1.49	0.0025
12	AST (IU/ml)	-	81.75 ± 63.78	76.46 ± 83.03	0.61
13	ALT (IU/ml)	-	83.70 ± 104.88	60.91 ± 83.98	0.08
14	SAP (IU/ml)	-	234.23 ± 112	316.96 ± 321.62	0.016
15	Total Protein (g/dl)	-	7.5 ± 0.49	7.4 ± 0.61	0.20

All values are expressed as n (%) or (mean ± SD) unless otherwise specified. p-value obtained from statistical analysis shows comparison between HCC, CLD, and Healthy subjects.

Abbreviations: AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; SAP, Serum alkaline phosphatase; PT, Prothrombin time; Hb, Hemoglobin; TLC, Total leucocyte count; PLT, Platelet count; AFP, Alpha-feto protein; HBV, Hepatitis B virus; HCV, Hepatitis C virus: NASH, Non-alcoholic steatosis Hepatitis; HVOTO, Hepatic venous outflow tract obstruction.

Bold values are statistically significant (p<0.05).