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Schematic diagram of modification by site directed nuclease (SDN- 1, SDN-2 and SDN-3) types. Double strand break (DSB) is repaired via non-homologous end joining (NHEJ) or homologous recombination (HR). SDN1 results in random insertion/deletion, SDN2 induces addition of few nucleotides and SDN3 inserts a DNA fragment.
