Table 1.
Species wise distribution of Fosfomycin MIC 50/90along with Fosfomycin and Nitrofurantoin resistance rates.
| Organism | Fosfomycin MIC 50/90 (mg/L) (MIC range) (mg/L) | Fosfomycin resistance (%) | NIT resistance (%) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||||||
| AD | E-test | DD | ||||||||||||||||
|
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| AD | E-test | CLSI | EUCAST | CLSI | EUCAST | CLSI | EUCAST | |||||||||||
|
| ||||||||||||||||||
| S | I | R | S | R | S | I | R | S | R | S | I | R | S | R | ||||
| E. coli (113) | 8/64(8–512) | 0.25/64 (0.125–1024) | 92.9 | 0.9 | 6.2 | 86.7 | 13.3 | 92.9 | 0.9 | 6.2 | 89.4 | 10.6 | 92.2 | 0 | 8.8 | 88.5 | 11.5 | 14.2 |
| Klebsiella pneumoniae (38) | 8/64(8–512) | 8/128 (0.125–1024) | 92.1 | 0 | 7.9 | 86.9 | 13.1 | 86.8 | 5.3 | 7.9 | 89.5 | 10.5 | 84.2 | 0 | 15.8 | 50 | 50 | 50 |
| Other Enterobacterales (7)* | 8/16(8–16) | 0.125/64 (0.125–128) | 100 | 0 | 0 | 100 | 0 | 87.5 | 12.5 | 0 | 75 | 25 | 100 | 0 | 0 | 87.5 | 12.5 | 28.6 |
| Enterococcus spp. (8) | 8/256(8–512) | 0.125/512 (0.125–1024) | 87.5 | 0 | 12.5 | 87.5 | 12.5 | 87.5 | 0 | 12.5 | 75 | 25 | 75 | 12.5 | 12.5 | 62.5 | 37.5 | 25* |
| P. aeruginosa (14) | 8/32(8–64) | 8/32(0.125–64) | 100 | 0 | 0 | 92.9 | 7.1 | 100 | 0 | 0 | 92.9 | 7.1 | 100 | 0 | 0 | 92.9 | 7.1 | NA* |
| Total (181) | 8/64(8–512) | 0.5/64(0.125–1024) | 93.3 | 0.6 | 6.1 | 88.4 | 11.6 | 91.7 | 2.2 | 6.1 | 88.4 | 11.6 | 90 | 0.6 | 9.4 | 79.6 | 20.4 | 27.1 |
*Proteus mirabilis and Pseudomonas aeruginosa were excluded as they are intrinsically resistant to Nitrofurantoin, DD: Disc diffusion, AD: Agar dilution, (NIT) Nitrofurantoin, S: Susceptible, I: Intermediate, R: Resistant, CLSI: Clinical and Laboratory Standards Institute, EUCAST: European Committee on Antimicrobial Susceptibility Testing, MIC: Minimum inhibitory concentration