Table 3.
List of cytokines and chemokines expressed in PBMCs of a RRMS patient during the two separate visits
| Name of cytokine/chemokine | Concentration (pg/mL) | |||||
|---|---|---|---|---|---|---|
| Control | Anti-CD3/CD28 | Anti-CD3/CD28 + CP | ||||
| First visit | Second visit | First visit | Second visit | First visit | Second visit | |
| EGF | 82.39 | 180.12 | 94.12 | 300.08 | 112.27 | 272.9 |
| FGF-2 | OOR < | 42.43 | OOR < | 70.62 | 129.81 | 68.25 |
| FLT3L | OOR < | 9.81 | OOR < | 67.01 | OOR < | 66.33 |
| Fractalkine | OOR < | 29.44 | 0.86 | 26.24 | 293.4 | 39.06 |
| G-CSF | 0.25 | 2.43 | 0.12 | 374.54 | 74.33 | 375.41 |
| GM-CSF | 5.14 | 2.28 | 141.13 | 1707.13 | 182.51 | 1413.79 |
| GRO-α | 665.59 | 3465.25 | 636.01 | 10175.14 | 760.06 | 8832.99 |
| IFNα2 | OOR < | 1.26 | 2.57 | 2.69 | 131.35 | 3.59 |
| IFNγ | OOR < | 2.06 | 82.59 | 12233.24 | 98.29 | 11802.46 |
| IL-10 | OOR < | 56.04 | 13 | 6229.1 | 13.36 | 5782.19 |
| IL-12p40 | OOR < | 5.64 | OOR < | 8.41 | 77.86 | 7.43 |
| IL-12p70 | OOR < | OOR < | 1.26 | 6.41 | 36.31 | 10.89 |
| IL-13 | OOR < | 0.03 | 0.70 | 2872.78 | 15.32 | 2937.46 |
| IL-15 | OOR < | 1.25 | OOR < | 2.58 | 19.39 | 3.62 |
| IL-17A | OOR < | 4.31 | 47.38 | 1481.38 | 70.37 | 1216.88 |
| IL-18 | OOR < | 23.71 | OOR < | 40.14 | OOR < | 40.85 |
| IL-1α | 9.85 | 1.79 | 29.9 | 1953.87 | 147.78 | 1199.5 |
| IL-1β | 3.95 | 5.12 | 10.4 | 2922.84 | 17.41 | 2546.77 |
| IL1RA | OOR < | 326.32 | OOR < | 2868.95 | 24.08 | 3024.76 |
| IL-2 | OOR < | 5.03 | 68.14 | 3.04 | 58.55 | 7.9 |
| IL-3 | 1.72 | OOR < | 3.5 | 46.13 | 13.51 | 33.42 |
| IL-4 | OOR < | 1.99 | 2.34 | 6.61 | 30.48 | 10.9 |
| IL-5 | OOR < | 0.42 | 14.91 | 1928.04 | 16.87 | 2037.28 |
| IL-6 | 18.86 | 7.48 | 30.93 | 1751.54 | 57.34 | 1803.72 |
| IL-7 | OOR < | 1.11 | OOR < | 4.88 | 3.38 | 4.32 |
| IL-8 | 3400.23 | 3705.31 | 2566.9 | 6951.18 | 3349.6 | 6212.4 |
| IL-9 | 0.21 | 0.32 | 3.97 | 387.37 | 10.26 | 355.93 |
| IP-10 | 5.89 | 334.69 | 131.42 | 11356.7 | 274.43 | 10994.14 |
| MCP-1 | 1759.08 | 2139.22 | 483.01 | 2345.07 | 778.83 | 2114.02 |
| MCP-3 | OOR < | 128.01 | OOR < | 12859.54 | OOR < | 11766.62 |
| MDC | 255.85 | 1196.56 | 161.47 | 6297.77 | 281.54 | 5652.95 |
| MIP-1α | 109.83 | 45.97 | 275.69 | 1692.36 | 324.32 | 1805.45 |
| MIP-1β | 42.13 | 12.61 | 360.49 | 10759.25 | 386.2 | 10168.86 |
| PDGF-AA | 255.38 | 890.95 | 359.73 | 1084.4 | 394.32 | 1105.17 |
| PDGF-BB | 1046.81 | 29230.55 | 483.98 | OOR > | 497.1 | 39065.12 |
| RANTES | OOR > | 2572.38 | OOR > | OOR > | OOR > | OOR > |
| sCD40L | 97.83 | 107.71 | 99.38 | 129.77 | 71.9 | 110.99 |
| TGF-α | OOR < | 3.75 | OOR < | 79.8 | 4.35 | 86.46 |
| TNF-α | 59.25 | 19.65 | 508.67 | 2075.17 | 652.95 | 2192.85 |
| TNF-β | OOR < | 1.64 | 17.68 | 940.8 | 97.96 | 1223.87 |
| VEGF-A | OOR < | 99.73 | OOR < | 7.82 | 158.29 | 9.35 |