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. 2021 Dec 6;1:73. doi: 10.1038/s43705-021-00077-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Error profiles of amplicon sequencing data from 234 bacterial strains sequenced on the Illumina platform. B Percentage of perfectly aligned reads after correction with different methods, including samples generated from strains with or without polymorphic copies of the 16S rRNA gene. C Evaluation of the influence of community complexity on the performance of different methods, measured as a deviation from the ground truth using Bray-Curtis dissimilarities. The columns represent the different methods and the rows correspond to the number of strains used to generate the SynCom mock community data. The values inside the heatmap refer to the averaged Bray-Curtis dissimilarities over 20 replicates for each SynCom combination.