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. 2022 Oct 20;2:103. doi: 10.1038/s43705-022-00187-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — I Phagocytosis metabolism. II Glycolysis. III TCA cycle. IV Ammonium metabolism. V Urea cycle. VI Nitrogen transport. Color bar denotes gene expression level (normalized by FPKM). Note that the expression of cathepsin was so high (FPKM = 21984.18) that it far exceeds the color scale used to properly indicate the differential expression of other genes. Stx Syntaxin, Rab5 Ras-related protein Rab5, VPS34 Phosphatidylinositol, 3-kinase vps34, vATPase V-type proton ATPase, Rab7 Ras-related protein Rab7, NOS Nitric oxide synthase, Sec61 Protein transport protein Sec61, TAP ABC transporter B family, AAD amino acid deaminase, GPI Glucose-6-phosphate isomerase, PFK Phosphofructokinase, FBA Fructose-bisphosphate aldolase, GPD Glyceraldehyde-3-phosphate dehydrogenase, PGK Phosphoglycerate kinase, BDPM 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, ENO Enolase, PK Pyruvate kinase, PDE1 Pyruvate dehydrogenase E1 component, PDE2 Pyruvate dehydrogenase E2 component, PC Pyruvate carboxylase, CS Citrate synthase, ACL ATP-citrate (pro-S-)-lyase, AH Aconitate hydratase, ICD Isocitrate dehydrogenase [NADP], ODE1 2-oxoglutarate dehydrogenase complex component E1, ODE2 2-oxoglutarate dehydrogenase complex component E2, SCS Succinyl-CoA synthetase, FR Fumarate reductase, SDF Succinate dehydrogenase [ubiquinone] flavoprotein subunit, FH1 Fumarate hydratase class I, MD Malate dehydrogenase, AMT Ammonium transporter, GS Glutamine synthetase, GLTS Glutamate synthase, GTD NAD-specific glutamate dehydrogenase, CPS Carbamoyl-phosphate synthase [ammonia], OCT Ornithine carbamoyltransferase, ASS Argininosuccinate synthase, ASL Argininosuccinate lyase, ARG Arginase.