Skip to main content
. 2022 Nov 9;50(20):11426–11441. doi: 10.1093/nar/gkac950

Figure 3.

Figure 3.

rG4detector reveals G3BP1 association with rG4-forming sequences is enhanced under stress. Analysis of G3BP1 eCLIP data from Markmiller et al. (48) reveals (A) stress-dependent enrichment in binding of single, double, or triple guanine-rich sequences by G3BP1 relative to basal conditions. (B) Comparison of the sequence length in basal and stress groups. (C) Comparison of the distribution of rG4 propensity scores under stress and basal conditions. (D) Distribution of predicted rG4 propensity scores under stress and basal conditions by rG4detector, G4Hunter, G4NN, and cGcC-scoring. Data standardized to obtain a mean of zero and standard deviation of 1. Line – median, cross – mean. (E) Categorical rG4 propensity scores to bins by RSR-ratio values: ‘low’ (0 to 1), ‘moderate’ (1 to 2) and ‘high’ (2+). (F) The fraction of rG4-containing sequences under stress and basal conditions. Pairwise Mann–Whitney test ****P < 0.0001, ns – non significant. (A–D); Pearson's chi-squared test with Yates’ continuity correction (F).