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. 2022 Nov 9;50(20):11442–11454. doi: 10.1093/nar/gkac990

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Genome-wide characterization of MPRA. (A) The prevalence of MpraNet defined positive and background variants are compared for promoter and enhancer regions. (B) The distribution of regulatory regions in which MpraNet positives and the background genome are located is compared. (C) The functional annotation scores of MpraNet positive and background variants are compared. (D, E) The mean MpraNet phred score of common and rare variants are compared and then the allele frequencies of MpraNet positives and the background genome are compared. (F) MpraNet performance is measured between the top hits of a PheWAS and a background set.