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Calculated Ki values deduced by fitting the Morrison equation to the data. Gibbs free enthalpies ΔG° were calculated using the equation ΔG° = –RTln(Ki), with R = 1.987 cal mol−1 K−1 and T = 303.15 K
| Compound composition | K i (μM) | ΔG° (kcal mol−1) | ΔΔG° (kcal mol−1) |
|---|---|---|---|
| RNA(a) | 0.93 ± 0.07 | −8.37 | NA |
| 2′F-RNA (26) | 0.056 ± 0.002 | −10.05 | −1.68 |
| HNA (27) | 17 ± 1 | −6.60 | +1.77 |
| 2′F-ANA (28) | 2.4 ± 0.1 | −7.80 | +0.57 |
| DNA (29) | 8.0 ± 0.6 | −7.07 | +1.30 |
(a) 8-nt peptidyl-RNA (32).
