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. 2022 Nov 2;50(20):11924–11937. doi: 10.1093/nar/gkac961

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The 40S head is stabilized in the export-competent state RRP12. (A) Two views of the molecular models of human states RRP12-A1 and RRP12-B3; all assembly factors are indicated. (B) The position at which the middle region of LTV1 interacts with domain IV of TSR1 in state RIOK2-C is occupied by an unidentified factor in the human state UTP14. (C) In human state UTP14, UTP14 interacts with PNO1. Together, these two interact with the 3' region of the 18S rRNA and ITS1 rRNA. (D) The sequence of maturation events occurring in the CPK and 3' regions of the 18S rRNA (from left to right: states UTP14, RRP12-A1, RRP12-A2, RRP12-A3 and RRP12-B1). (E) In the transition from state RRP12-A to RRP12-B2, the N-terminal ARM repeat of RRP12 slides to the one side. The movement of the N terminus is indicated with dash lines.