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. 2022 Nov 2;50(20):11924–11937. doi: 10.1093/nar/gkac961

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The complete activity cycle of TSR1 in early head maturation. (A) The complete activity cycle of TSR1. The immature/mature h18 of the 18S rRNA, Bud23/BUD23 and Tsr1/TSR1 are shown in ribbon representation (left to right: states Tsr1-1, Tsr1-2, Tsr1-3, RRP12-A, RRP12-B1 to RIOK2-D1 and RIOK2-D2). The overall positions are shown in thumbnails. (B) The very N terminus of the yeast Tsr1 (left, state Tsr1) and human TSR1 (right, from state UTP14 to RRP12-A) interferes with the maturation of h28 of the 18S rRNA. (C, D) The conformation of domain IV of TSR1 in states RIOK2-C and RIOK2-D1. Maturation of h34 of the 18S rRNA pushes domain IV of TSR1 outward. The movements of h34 and domain IV of TSR1 are indicated by arrows.