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. 2021 Mar 26;1:8. doi: 10.1038/s43705-021-00003-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Heatmap depicting the abundance (log₂) of pro- and anti-inflammatory cytokines at 1 year of age. Cytokine levels were measured by stimulating MoDCs from healthy donors (Donor 1–4) with LPS isolated from faecal samples of CSD and VD neonates. b Boxplots depicting the TNF-α levels in both groups (CSD and VD) at day 5 after birth and 1 year of age. Paired two-way ANOVA (analysis of variance) p-values are listed in the plot to depict significant differences. ***p-value < 0.001. c Correlation of TNF-α levels (row 1) with the relative abundance of metagenomic OTUs based on canonical correlation analysis. Filled squares indicate significantly correlated taxa, whereas colour indicates positive (red) or negative (blue) correlation.