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MITF transcriptionally regulates STIM1 expression during melanogenesis. Our data demonstrates that downstream of αMSH stimuli, MITF-M regulates STIM1 expression by enhancing transcription of STIM1. We show that MITF-M binds on the STIM1 promoter and thereby drives STIM1 promoter activity and its expression. αMSH, α-Melanocyte Stimulating Hormone; MITF, Microphthalmia-associated transcription factor; STIM1, Stromal Interaction Molecule1.
