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. 2022 Nov 9;298(12):102685. doi: 10.1016/j.jbc.2022.102685

Figure 6.

Figure 6

Proposed mechanism for B1 interaction with PS and subsequent impact of ATP11A on B1 signaling.A, without PS engagement of the B1 NTF, B1 exhibits minimal G protein–dependent signaling. B, B1FL binds to externalized PS, which triggers a conformational change in the NTF and results in enhanced G protein–dependent signaling. C, the flippase ATP11A binds to B1 and also reduces PS exposure, thereby lowering B1 signaling activity when the flippase is active. NTF, N-terminal fragment; PS, phosphatidylserine.