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. 2022 Dec 2;10(12):e005834. doi: 10.1136/jitc-2022-005834

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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In situ vaccination of CPMV with anti-CD40 generates better efficacy. (A) Schematic presentation of experimental setup. Two-tumor bearing mice of B16F10 or 4T1 had their first tumor treated with weekly intratumoral injection of CPMV and/or CD40 agonist antibody (aCD40). (B, C) Growth curves for corresponding tumors. Tumor growth curves were analyzed using two-way analysis of variance, with p>0.05 as ns, p<0.05 as *, p<0.01 as **, and p<0.001 as ***. All experiments are repeated at least once and each with n≥3 mice/group. aCD40, agonist anti-CD40; CPMV, cowpea mosaic virus; I.D., intradermal; PBS, phosphate buffered saline.