. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2022;88(4):1385–1395. doi: 10.3233/JAD-215665

Table 4.

Multivariate regression analysis: Association between GDS and cognitive domains among different AT(N) categories overall and by sex

	Biomarker	Memory				Executive Function
	Biomarker	β	t	p	95% CI	β	t	P	95% CI

All^*	Normal biomarkers (N = 161)	−0.045	−0.589	0.556	−0.079, 0.043	−0.079	−1.014	0.312	−0.119, 0.038
	AD continuum (N = 482)	−0.174	−4.050	<0.001	−0.138, −0.048	−0.129	−2.959	0.003	−0.138,−0.028
	SNAP (N = 225)	−0.172	−2.828	0.005	−0.156, −0.028	−0.197	−3.270	0.001	−0.204, −0.051
Women^**	Normal biomarker (N = 86)	0.085	0.769	0.444	−0.046, 0.104	−0.003	−0.028	0.978	−0.105, 0.103
	AD continuum (N = 216)	−0.120	−1.768	0.079	−0.142, 0.008	−0.030	−0.453	0.651	−0.104, 0.065
	SNAP (N = 100)	−0.133	−1.352	0.180	−0.178, 0.034	−0.259	−2.878	0.005	−0.280, −0.051
Men^**	Normal biomarker (N = 75)	−0.235	−2.041	0.045	−0.208, −0.002	−0.278	−2.441	0.017	−0.261,−0.026
	AD continuum (N = 266)	−0.223	−3.826	<0.001	−0.163,−0.052	−0.203	−3.531	<0.001	−0.205, −0.058
	SNAP (N = 125)	−0.218	−2.602	0.010	−0.190, −0.026	−0.149	−1.814	0.072	−0.203, 0.009

Models are adjusted for age, sex, and education.

^**

Models adjusted for age and education. GDS, Geriatric Depression Scale; SNAP, suspect non-AD pathology. Standardized β coefficient is used throughout.