Table 2.
The association between cognitively stimulating, physically active/demanding, and socially engaged LAE change patterns and MCI reversion.
| Low-low | Low-medium | Low-high | Medium-low | Medium-medium | Medium-high | High-low | High-medium | High-high | |
|---|---|---|---|---|---|---|---|---|---|
| Cognitively stimulating | |||||||||
| No of reverters/ person years | 195/2,604 | 258/1,575 | 27/109 | 225/3,250 | 799/4,533 | 83/351 | 12/210 | 47/250 | 72/267 |
| Reversion rate | 28.6 | 59.3 | 79.4 | 28.6 | 64.5 | 79.0 | 21.4 | 65.3 | 87.8 |
| Model 1 | 1 ref | 1.85 (1.53–2.24)*** | 2.60 (1.73–3.90)*** | 0.85 (0.70–1.03) | 1.88 (1.60–2.21)*** | 2.32 (1.78–3.03)*** | 0.65 (0.36–1.16) | 1.95 (1.41–2.70)*** | 2.51 (1.90–3.33)*** |
| Model 2 | 1 ref | 1.94 (1.57–2.39)*** | 2.74 (1.78–4.21)*** | 0.89 (0.72–1.10) | 1.98 (1.65–2.38)*** | 2.45 (1.82–3.29)*** | 0.74 (0.40–1.37) | 2.04 (1.44–2.89)*** | 2.65 (1.95–3.61)*** |
| Model 3 | 1 ref | 1.88 (1.50–2.35)*** | 2.57 (1.61–4.11)*** | 0.86 (0.68–1.09) | 1.90 (1.56–2.32)*** | 2.22 (1.60–3.08)*** | 0.81 (0.44–1.51) | 1.78 (1.20–2.65)** | 2.53 (1.80–3.57)*** |
| Physically active/demanding | |||||||||
| No of reverters/ person years | 69/1,147 | 66/511 | 51/212 | 137/2,083 | 289/1,759 | 290/1,189 | 74/1,278 | 243/1,497 | 385/1,666 |
| Reversion rate | 21.8 | 42.9 | 77.3 | 25.0 | 57.0 | 84.5 | 23.7 | 58.8 | 79.7 |
| Model 1 | 1 ref | 1.93 (1.38–2.71)*** | 3.18 (2.21–4.59)*** | 1.02 (0.76–1.36) | 2.24 (1.72–2.92)*** | 2.96 (2.25–3.88)*** | 0.87 (0.63–1.21) | 2.13 (1.62–2.80)*** | 2.79 (2.14–3.65)*** |
| Model 2 | 1 ref | 1.91 (1.34–2.74)*** | 3.24 (2.19–4.79)*** | 1.04 (0.76–1.41) | 2.27 (1.71–3.00)*** | 2.93 (2.20–3.91)*** | 0.90 (0.63–1.28) | 2.08 (1.55–2.78)*** | 2.84 (2.14–3.77)*** |
| Model 3 | 1 ref | 1.86 (1.27–2.73)** | 3.20 (2.10–4.88)*** | 0.97 (0.69–1.35) | 2.13 (1.56–2.91)*** | 2.61 (1.89–3.60)*** | 0.85 (0.57–1.25) | 1.93 (1.39–2.69)*** | 2.62 (1.90–3.63)*** |
| Socially engaged | |||||||||
| No of reverters/ person years | 589/6,016 | 91/460 | 211/1,001 | 82/895 | 20/112 | 57/261 | 246/2,469 | 65/370 | 355/1,546 |
| Reversion rate | 36.6 | 72.2 | 72.8 | 35.8 | 62.5 | 76.0 | 41.7 | 71.4 | 80.5 |
| Model 1 | 1 ref | 1.78 (1.43–2.22)*** | 1.85 (1.58–2.17)*** | 0.90 (0.71–1.13) | 1.36 (0.87–2.13) | 1.75 (1.33–2.30)*** | 0.94 (0.80–1.09) | 1.42 (1.09–1.84)** | 1.70 (1.47–1.96)*** |
| Model 2 | 1 ref | 1.94 (1.53–2.48)*** | 1.95 (1.64–2.32)*** | 0.93 (0.73–1.20) | 1.28 (0.77–2.11) | 1.82 (1.35–2.46)*** | 0.97 (0.83–1.15) | 1.41 (1.07–1.86)* | 1.79 (1.54–2.09)*** |
| Model 3 | 1 ref | 2.05 (1.58–2.65)*** | 1.98 (1.64–2.40)*** | 0.96 (0.73–1.26) | 1.26 (0.75–2.11) | 1.77 (1.29–2.43)*** | 0.95 (0.79–1.14) | 1.30 (0.94–1.80) | 1.67 (1.40–1.98)*** |
*
P < 0.05
**
P < 0.01
***
P < 0.001.
Model 1 Adjusted for age (continuous), gender.
Model 2 Adjusted for model 1 plus residence, years of schooling, marital status, economic status, living pattern, number of people living with.
Model 3 Adjusted for model 2 plus tobacco smoking, alcohol drinking, regular exercise, ADL, IADL, chronic disease (hypertension, diabetes, heart disease, stroke or CVD, cataract, digestive system disease, arthritis, Parkinson's disease).