Table 4.
The association between LAE change patterns and MCI reversion in subgroups.
| Low-low | Low-medium | Low-high | Medium-low | Medium-medium | Medium-high | High-low | High-medium | High-high | |
|---|---|---|---|---|---|---|---|---|---|
| Age | |||||||||
| Younger elderly | |||||||||
| No of reverters/ person years | 6/72.0 | 11/56 | 19/78 | 11/150 | 43/179 | 76/302 | 15/147 | 61/341 | 274/1,030 |
| Reversion rate | 30.0 | 64.7 | 86.4 | 30.6 | 81.1 | 90.5 | 40.5 | 73.6 | 90.4 |
| HR (95%CI) | 1 ref | 1.62 (0.53–5.01) | 1.70 (0.57–5.07) | 0.50 (0.15–1.67) | 1.88 (0.67–5.24) | 1.92 (0.70–5.28) | 1.05 (0.35–3.10) | 1.41 (0.51–3.86) | 1.94 (0.72–5.20) |
| Octogenarian | |||||||||
| No of reverters/ person years | 43/505 | 33/190 | 42/168 | 42/639 | 85/469 | 86/375 | 38/616 | 66/448 | 150/640 |
| Reversion rate | 32.1 | 57.9 | 80.8 | 25.8 | 64.9 | 78.9 | 28.6 | 57.9 | 80.6 |
| HR (95%CI) | 1 ref | 2.23 (1.36–3.65) ** | 2.86 (1.76–4.65) *** | 0.77 (0.48–1.26) | 1.98 (1.29–3.05) ** | 2.42 (1.58–3.70) *** | 0.65 (0.39–1.09) | 1.52 (0.95–2.42) | 2.37 (1.56–3.60) *** |
| Nonagenarian | |||||||||
| No of reverters/ person years | 50/1,181 | 20/230 | 26/140 | 48/997 | 42/383 | 38/211 | 34/705 | 43/305 | 46/245 |
| Reversion rate | 15.2 | 30.3 | 65.0 | 17.1 | 38.2 | 56.7 | 17.4 | 47.8 | 63.9 |
| HR (95%CI) | 1 ref | 2.14 (1.23–3.70) ** | 3.48 (1.96–6.20) *** | 1.02 (0.66–1.59) | 2.22 (1.38–3.55) ** | 3.22 (1.94–5.36) *** | 1.15 (0.71–1.87) | 2.31 (1.36–3.93) ** | 3.67 (2.24–6.03) *** |
| Sex | |||||||||
| Male | |||||||||
| No of reverters/ person years | 34/386 | 20/152 | 36/143 | 28/420 | 61/357 | 78/302 | 26/386 | 71/351 | 178/665 |
| Reversion rate | 30.4 | 44.4 | 78.3 | 23.1 | 61.6 | 84.8 | 25.2 | 69.6 | 87.7 |
| HR (95%CI) | 1 ref | 1.41 (0.79–2.52) | 2.37 (1.40–4.04) ** | 0.62 (0.35–1.09) | 1.62 (1.01–2.61) * | 2.29 (1.45–3.63) *** | 0.71 (0.41–1.24) | 1.67 (1.02–2.71) * | 2.10 (1.34–3.27) ** |
| Female | |||||||||
| No of reverters/ person years | 65/1,371 | 44/324 | 51/242 | 73/1,366 | 109/674 | 122/587 | 61/1,082 | 99/743 | 292/1,250 |
| Reversion rate | 17.6 | 46.3 | 75.0 | 20.3 | 55.9 | 72.6 | 23.3 | 53.2 | 81.6 |
| HR (95%CI) | 1 ref | 2.75 (1.82–4.15) *** | 3.47 (2.26–5.31) *** | 1.01 (0.69–1.48) | 2.68 (1.87–3.84) | 2.99 (2.08–4.29) *** | 1.08 (0.73–1.61) | 2.02 (1.39–2.94) *** | 3.10 (2.20–4.37) *** |
| Economic status | |||||||||
| Favorable | |||||||||
| No of reverters/ person years | 76/1,446 | 52/366 | 69/286 | 84/1,437 | 130/754 | 144/653 | 71/1,205 | 129/827 | 366/1,456 |
| Reversion rate | 19.2 | 48.1 | 81.2 | 21.5 | 60.2 | 74.6 | 23.9 | 58.6 | 84.3 |
| HR (95%CI) | 1 ref | 2.38 (1.63–3.48) *** | 3.18 (2.19–4.61) *** | 0.93 (0.66–1.32) | 2.41 (1.75–3.33) *** | 2.85 (2.08–3.93) *** | 0.96 (0.67–1.38) | 1.97 (4.41–2.74) *** | 2.86 (2.11–3.89) *** |
| Unfavorable | |||||||||
| No of reverters/ person years | 84/303 | 32/110 | 29/100 | 87/344 | 76/261 | 66/233 | 67/260 | 68/267 | 124/447 |
| Reversion rate | 25.0 | 37.5 | 62.1 | 18.4 | 51.3 | 83.3 | 23.9 | 60.3 | 81.5 |
| HR (95%CI) | 1 ref | 1.44 (0.68–3.05) | 2.00 (0.94–4.25) | 0.61 (0.30–1.25) | 1.71 (0.91–3.22) | 2.44 (1.29–4.60) ** | 0.89 (0.42–1.90) | 1.83 (0.93–3.58) | 2.17 (1.18–3.98) * |
| Marital status | |||||||||
| Married | |||||||||
| No of reverters/ person years | 17/222 | 18/122 | 29/114 | 16/253 | 47/211 | 69/268 | 31/316 | 59/304 | 225/844 |
| Reversion rate | 27.9 | 50.0 | 78.4 | 23.9 | 75.8 | 89.6 | 39.2 | 71.2 | 88.6 |
| HR (95%CI) | 1 ref | 1.54 (0.80–2.98) | 2.26 (1.23–4.16) ** | 0.57 (0.28–1.14) | 2.19 (1.25–3.83) ** | 2.32 (1.34–4.02) ** | 1.05 (0.58–1.91) | 1.75 (1.00–3.07) | 2.19 (1.30–3.70) ** |
| Divorced/ widowed /never | |||||||||
| No of reverters/ person years | 82/1,536 | 46/354 | 58/272 | 85/1,533 | 123/817 | 131/621 | 56/1,152 | 111/790 | 245/1,071 |
| Reversion rate | 19.5 | 44.2 | 75.3 | 20.6 | 53.2 | 71.6 | 19.6 | 54.1 | 79.8 |
| HR (95%CI) | 1 ref | 2.45 (1.65–3.62) *** | 3.30 (2.20–4.93) *** | 0.96 (0.68–1.36) | 2.19 (1.56–3.07) *** | 2.86 (2.04–4.00) *** | 0.84 (0.57–1.24) | 1.88 (1.32–2.70) ** | 3.01 (2.17–4.17) *** |
| Living pattern | |||||||||
| Living with family members | |||||||||
| No of reverters/ person years | 77/1,471 | 51/360 | 69/310 | 76/1,385 | 117/687 | 152/682 | 71/1,185 | 129/847 | 379/1,510 |
| Reversion rate | 18.9 | 47.2 | 75.8 | 20.0 | 59.3 | 75.2 | 23.7 | 57.6 | 85.2 |
| HR (95%CI) | 1 ref | 2.36 (1.64–3.40) *** | 3.23 (2.28–4.59) *** | 0.88 (0.62–1.23) | 2.60 (1.91–3.54) *** | 3.05 (2.25–4.14) *** | 1.02 (0.72–1.45) | 2.12 (1.54–2.92) *** | 3.06 (2.28–4.10) *** |
| Alone or at nursing home | |||||||||
| No of reverters/ person years | 21/28.8 | 13/40.6 | 18/78.3 | 25/25.3 | 53/54.6 | 48/82.8 | 16/25.0 | 41/64.1 | 90/78.3 |
| Reversion rate | 284 | 116 | 76 | 399 | 344 | 207 | 276 | 247 | 402 |
| HR (95%CI) | 1 ref | 1.28 (0.53–3.11) | 1.46 (0.45–4.70) | 0.80 (3.56–1.80) | 1.11 (0.49–2.50) | 1.37 (0.62–3.04) | 0.61 (0.25–1.51) | 1.06 (0.46–2.44) | 1.24 (0.57–2.68) |
*
P < 0.05
**
P < 0.01
***
P < 0.001.
Adjusted for age (continuous), gender, residence, years of schooling, marital status, economic status, living pattern, number of people living with, tobacco smoking, alcohol drinking, regular exercise, ADL, IADL, chronic disease (hypertension, diabetes, heart disease, stroke or CVD, cataract, digestive system disease, arthritis, Parkinson's disease).