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Terminal (A) and internal (B) cross-linking strategies by CuAAC to pre-shape a linear ssDNA as a substrate (dC-containing oligo) and as an inhibitor of A3BCTD (dZ-containing oligo). (C) Alkyne (Y) and azide (dRN3) modifications used in the sequence for terminal cross-linking strategy. (D) Alkyne (dUE) and azide (dAN3) modifications used for internal cross-linking strategy.
