Table 5. K_i Values of Inhibitors of Wild-Type A3A^a.

inhibitor	Ki (nM)
FdZ-linear,215′-AT3FdZAT3	2400 ± 940
cross-link, dZ[UE(−2), AN3(+1)]X	360 ± 120

^aConditions: 50 mM Na⁺/K⁺ phosphate buffer, pH 7.4 supplemented with 100 mM NaCl, 1 mM TCEP, 100 μM DSS, and 10% D₂O; enzyme concentration: 140 nM; substrate concentration (dC-hairpin): 500 μM. K_m for dC-hairpin against A3A is 21 μM, k_cat is 0.13 s^–1, and k_cat/K_m is 6.2 s^–1 mM^–1.