Scheme 3. Investigating the Impact of the Electron Withdrawing Group and the Generation of Optically Active Derivatives.

Green box: combined yield of both cis and trans isomers and dr determined by ¹⁹F NMR with α,α,α-trifluorotoluene as an internal standard.

Gray box: isolated yield following column chromatography, average of 2 runs, 0.50 mmol scale.

0.20 mmol scale.

er determined by esterification to form 3e, followed by analysis by HPLC.