TABLE 2:

Pooled Risks of Adverse Neurodevelopmental Outcomes After Preterm Brain Injury

	IVH Grade 1–2	IVH Grade 3–4	Cystic PVL
Moderate-severe neurodevelopmental impairment	OR 1.32 (1.1–1.58) I2 = 41%, 8 studies; 9572 infants, aOR 1.35 (1.05–1.75) I2 = 49%, 5 studies	OR 3.27 (2.44–4.39) I2 = 81%, 7 studies, aOR 4.26 (3.25–5.59) I2 = 34%, 4 studies	OR 3.63 (2.49–5.31) I2 = 0%, 3 studies, aOR 2.38 (0.73–7.7) I2 = 94%, 3 studies
Motor	BSID II PDI < 70, OR 1.72(0.96–3.1) I2 = 82%, 3 studies; 2483 infants	BSID II PDI < 70, OR 2.7 (1.52–4.8) I2 = 73%, 2 studies	BSID II PDI < 70, OR 5.3 (3–9.36) I2 = 28%, 3 studies
Cerebral palsy	OR 1.76 (1.39–2.24) I2 = 52%, 10 studies; 11 018 infants	OR 4.98 (4.13–6.00) I2 =37%, 7 studies, moderate to severe cerebral palsy, OR 2.39 (1.49–3.85) I2 = 0%, 2 studies	OR 14.91 (7.3–30.46) I2 = 87%, 5 studies
Cognitive impairment	BSID II MDI < 70, OR 1.79 CI (1.09–2.95) I2 = 80%, 4 studies; 3646 infants	BSID II MDI < 70, OR 2.83 (1.54–5.2) I2 = 78%, 3 studies, Bayley-III scores <85, OR 2.3 (1.67–3.15) I2 = 0%, 2 studies	BSID II MDI < 70, OR 3.48 95% CI (2.18–5.53) I2 = 0%, 3 studies
Hearing impairment	OR 1.83 CI (1.03–3.24) I2=62%, 7 studies; 8273 infants	OR 2.44 (1.42–4.2) I2 = 52%, 5 studies; 7224 infants	—
Visual impairment	OR 1.77 (1.08–2.9) I2 = 0%, 6 studies; 7881 infants	OR 5.42 (2.77–10.58) I2 = 50%, 5 studies; 7203 infants	—

BSID, Bayley Scale of Infant Development; MDI, Mental Development Index; PDI, Psychomotor Development Index; —, not applicable.