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. 2022 Dec 6;2022(12):CD012026. doi: 10.1002/14651858.CD012026.pub2

Clark 2010.

Study characteristics
Methods Study design
  • Parallel RCT


Duration of study
  • Not reported


Duration of follow‐up
  • 7 months

Participants General information
  • Setting: not reported

  • Country: USA

  • Inclusion criteria: serum phosphorus levels of ≥ 6.5 for ≥ 3 consecutive months

  • Exclusion criteria: not reported


Baseline characteristics
  • Number: intervention group (6); control group (6)

  • Mean age ± SD (years): not reported

  • Sex (M/F): not reported

  • Stage of CKD: ESKD on dialysis

Interventions Intervention type
  • Self‐management: individual versus control


Intervention group
  • Met with the study physician monthly for 3 months with a review of food diaries, binder use and compliance, proper diet choices and descriptions of potential vascular complications (in addition to the standard dietician visit)


Control group
  • Met with the dietician monthly with a review of labs and diet


Co‐interventions
  • Both groups were also seen monthly by their nephrologists

Outcomes Bloods
  • PO4, Ca x PO4 product

Notes Conflict of interest
  • Not reported


Funding source
  • Not reported


Other information
  • Abstract‐only publication

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Insufficient information to permit judgement
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)
All outcomes High risk Unclear whether personnel were blinded. Participants could not of been blinded
Blinding of outcome assessment (detection bias)
Objective outcomes Low risk Probably not blinded but objective outcome measures
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Insufficient information; does not seem to be any dropouts but a very small sample size
Selective reporting (reporting bias) Unclear risk Unclear
Other bias High risk No mention of whether control and intervention were significantly different. Small sample size. Was the intensive study physician trained in nutrition education?