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. 2022 Dec 6;20:563. doi: 10.1186/s12967-022-03792-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Changes in T cells and stromal cells before and after NACT. A Expression of cytotoxicity (top panel), proliferation (middle panel), exhaustion (bottom panel) and other T cell functional status-related gene sets in different T cell types before and after NACT. B GSVA of differently expressed pathways in CD4+ T cells (top panel), CD8+ T cells (middle panel), and CD4+ Tregs (bottom panel) before and after NACT. C Volcano plots showing DEGs in CD4+ T cells (top panel) and CD8+ T cells (bottom panel) before and after NACT. D GSVA of differently expressed pathways in endothelial cells (left panel), fibroblasts (middle panel), and myofibroblasts (right panel) before and after NACT. E Volcano plots showing DEGs in fibroblasts (top panel) and myofibroblasts (bottom panel) before and after treatment. *P < 0.05; **P < 0.01; ***P < 0.001; n.s.: not significant