Table 2.
Multivariate analysis of overall survival for patients undergoing NACT
| CR/PR (n = 227) | SD/PD (n = 91) | NACT (n = 318) | ||||
|---|---|---|---|---|---|---|
| Adjust p-Value | Adjust OR (95%CI) | Adjust p-Value | Adjust OR (95%CI) | Adjust p-Value | Adjust OR (95%CI) | |
| Age | \ | \ | 0.108 | 0.925 (0.841, 1.017) | \ | \ |
| Hb | 0.093 | 0.978 (0.953, 1.004) | \ | \ | 0.300 | 0.989 (0.968, 1.010) |
| Tumor size | ||||||
| before NACT | 0.760 | 0.926 (0.563, 1.522) | 0.945 | 1.029 (0.457, 2.319) | 0.650 | 1.082 (0.771, 1.518) |
| after NACT | 0.055 | 1.928 (0.987, 3.769) | 0.463 | 1.306 (0.641, 2.660) | 0.096 | 1.246 (0.962, 1.614) |
| Approach of surgery | \ | \ | \ | \ | 0.085 | 0.305 (0.079, 1.176) |
| FIGO | 0.272 | 1.920 (0.599, 6.152) | \ | \ | \ | \ |
| > 1/2 depth of cervical invasion | 0.154 | 2.243 (0.739, 6.806) | 0.325 | 2.357 (0.428, 12.97) | 0.046 | 2.608 (1.017, 6.691) |
| LVSI | \ | \ | \ | \ | 0.242 | 1.901 (0.648, 5.577) |
| Vagina involvement | 0.523 | 0.427 (0.031, 5.831) | 0.165 | 6.154 (0.472, 80.171) | 0.676 | 1.476 (0.238, 9.157) |
| Uterus involvement | \ | \ | \ | \ | 0.927 | 1.076 (0.227, 5.109) |
| Lymph node metastasis | 0.464 | 1.591 (0.46, 5.507) | \ | \ | 0.938 | 1.042 (0.368, 2.946) |
Candidate variables with a p-value of < 0.2 in univariate analysis of Cox proportional hazards regression were included in the multivariable model and “\” meant the corresponding factor was not included
Abbreviations: OR Odds ratio, Hb Hemoglobin concentration, Plt Platelet concentration, BMI Body mass index, SCCA Squamous Cell Carcinoma Antigen, NACT Neoadjuvant chemotherapy, LVSI Lymphovascular space invasion