Table 2.
Seizure characteristics in relation to splenial changes on MRI
| Total (N = 123) | MRI change in splenium | |||
|---|---|---|---|---|
| Yes (N = 26) | No (N = 97) | P | ||
| Seizure present | 39 (31.7%) | 21 (80.8%) | 18 (18.6%) | < 0.001 |
| Number of anti-epileptics | 0.54 ± 1.03 | 1.77 ± 1.56 | 0.21 ± 0.46 | < 0.001 |
| Anti-epileptics used | ||||
| None | 84 (68.3%) | 5 (19.2%) | 79 (81.4%) | < 0.001 |
| 1 anti-epileptic | 27 (22.0%) | 10 (38.5%) | 17 (17.5%) | |
| 2 or more anti-epileptics, not including midazolam drip | 7 (5.7%) | 6 (23.1%) | 1 (1.0%) | |
| Includes midazolam drip | 5 (4.1%) | 5 (19.2%) | 0 (0.0%) | |
| Seizure frequencya | ||||
| None | 84 (68.9%) | 5 (20.0%) | 79 (81.4%) | < 0.001 |
| 1 seizure | 8 (6.6%) | 2 (8.0%) | 6 (6.2%) | |
| 2 or more seizures | 22 (18.0%) | 10 (40.0%) | 12 (12.4%) | |
| Status epilepticus | 8 (6.6%) | 8 (32.0%) | 0 (0.0%) | |
| Worst EEG background in first 24 hoursb | ||||
| Normal | 12 (9.8%) | 1 (3.8%) | 11 (11.5%) | < 0.001 |
| Mild to moderate | 90 (73.8%) | 13 (50.0%) | 77 (80.2%) | |
| Severe | 20 (16.4%) | 12 (46.2%) | 8 (8.3%) | |
| Seizure typec | ||||
| Clinical only | 3 (7.7%) | 2 (9.5%) | 1 (5.6%) | 0.375 |
| Electrographic only | 17 (43.6%) | 7 (33.3%) | 10 (55.6%) | |
| Clinical and electrographic | 19 (48.7%) | 12 (57.1%) | 7 (38.9%) | |
Data presented as mean ± standard deviation or counts (and percentages within each row). P-value for unpaired t-test for continuous variables or Chi-square analysis for categorical variables
aOne patient had unclear duration of clinical seizures at outside hospital prior to transfer to Rady’s Children’s Hospital; N = 122 for total neonates, N = 25 for yes splenium change group
bOne patient had video EEG done but information on EEG background in the first 24 hours was not available; N = 122 for total neonates, N = 96 for no splenium change group
cEighty-four neonates had no seizures; N = 39 for total neonates, N = 21 for yes splenium change group, N = 18 for no splenium change group